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Once intracellular lactate is sufficient to induce CD4 + T cell phenotype transformation, RORT-dependent IL-17 expression via activation of the PKM2-STAT3 axis would be initiated, confirming lactate as a critical mediator in inflammation-related diseases, including RA

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Some of these factors include the cellular composition and vascular nature of the tissue(s) in question

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Furthermore, the activation of the GIP receptor also improved glucose metabolism in diet-induced obese mice without changing body weight or fat mass [69]